For dogs suffering from, or at risk from, mixed parasitic infections: For the treatment and prevention of flea infestation (Ctenocephalides felis), treatment of biting lice (Trichodectes canis), treatment of ear mite infestation (Otodectes cynotis), sarcoptic mange (caused by Sarcoptes scabiei var. canis), demodicosis (caused by Demodex canis), prevention of heartworm disease (L3 and L4 larvae of Dirofilaria immitis) and angiostrongylosis (L4 larvae and immature adults of Angiostrongylus vasorum), treatment of Angiostrongylus vasorum and Crenosoma vulpis and treatment of infections with gastrointestinal nematodes (L4 larvae, immature adults and adults of Toxocara canis, Ancylostoma caninum and Uncinaria stenocephala, adults of Toxascaris leonina and Trichuris vulpis). The product can be used as part of a treatment strategy for flea allergy dermatitis (FAD).

How It Works

Imidacloprid is effective against both adult fleas and larval flea stages. After contact with an animal treated with the product, flea larvae in the pet's environment are killed. Imidacloprid has a high affinity in the post-synaptic region of the flea's central nervous system ( CNS) for the nicotinergic acetylcholine receptors. Paralysis and death result from the resulting inhibition of cholinergic transmission in insects. Moxidectin is a parasiticide active against many parasites that are internal and external. Moxidectin is active against Dirofilaria immitis larval stages (L3, L4). Against gastrointestinal nematodes, it is also active. Moxidectin communicates with chloride channels that are GABA and glutamate-gated. This leads to the opening at the postsynaptic junction of the chloride channels, the inflow of chloride ions and the activation of an irreversible resting state. The outcome is flaccid paralysis of the parasites involved, accompanied by death and/or expulsion.

INGREDIENTS

Instructions

Applied monthly, Advocate will control lice. For puppies from 7 weeks and kittens from 9 weeks of age, Advocate is safe to use. Not only does Advocate have a broad safety margin for pets, but also for their owners.